Amit Singer: Software for near-atomic resolution using cryo-electron microscopy

A software package aims to aid drug design and biomedical research by making it easy to construct 3D images of proteins and other molecules using one of the world’s most powerful microscopes. Amit Singer and his team are developing a package they call Algorithms for Single Particle Reconstruction, or ASPIRE, that takes in 2D images captured by cryo-electron microscopy and produces reliable 3D structures without significant human intervention.